Loading...

Estrogen Receptor α L543A,L544A Mutation Changes Antagonists to Agonists, Correlating with the Ligand Binding Domain Dimerization Associated with DNA Binding Activity

A ligand-dependent nuclear transcription factor, ERα has two transactivating functional domains (AF), AF-1 and AF-2. AF-1 is localized in the N-terminal region, and AF-2 is distributed in the C-terminal ligand-binding domain (LBD) of the ERα protein. Helix 12 (H12) in the LBD is a component of the A...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Arao, Yukitomo, Hamilton, Katherine J., Coons, Laurel A., Korach, Kenneth S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774377/
https://ncbi.nlm.nih.gov/pubmed/23733188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463455
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!