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T cell populations in the pancreatic lymph node naturally and consistently expand and contract in NOD mice as disease progresses

Nonobese diabetic (NOD) mice develop spontaneous autoimmune Type 1 diabetes (T1D) that results from the destruction of insulin secreting β cells by diabetogenic T cells. The activation of autoreactive T cells occurs in the pancreatic lymph nodes (PLN) from where effector T cells migrate to the pancr...

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Bibliografiske detaljer
Main Authors: Marrero, Idania, Vong, Allen, Dai, Yang, Davies, Joanna D.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774157/
https://ncbi.nlm.nih.gov/pubmed/22580347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2012.04.004
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