The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis

Neuropilin 1 (NRP1) plays an important but ill-defined role in VEGF-A signaling and vascular morphogenesis. We show that mice with a knockin mutation that ablates the NRP1 cytoplasmic tail (Nrp1(cyto)) have normal angiogenesis but impaired developmental and adult arteriogenesis. The arteriogenic def...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Lanahan, Anthony, Zhang, Xi, Fantin, Alessandro, Zhuang, Zhen, Rivera-Molina, Felix, Speichinger, Katherine, Prahst, Claudia, Zhang, Jiasheng, Wang, Yingdi, Davis, George, Toomre, Derek, Ruhrberg, Christiana, Simons, Michael
Format: Artigo
Langue:Inglês
Publié: Cell Press 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774154/
https://ncbi.nlm.nih.gov/pubmed/23639442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.03.019
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