NS-398 reverses hypotension in endotoxemic rats: contribution of eicosanoids, NO, and peroxynitrite

We have previously demonstrated that inhibition of vasodilator prostanoids, PGI(2) and PGE(2), and nitric oxide (NO) synthsesis by a selective cyclooxygenase-2 (COX-2) inhibitor, NS-398, restores blood pressure as a result of increased systemic and renal levels of 20-hydroxyeicosatetraenoic acid (20...

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Main Authors: Tunctan, Bahar, Sari, Ayse Nihal, Kacan, Meltem, Unsal, Demet, Buharalioglu, C. Kemal, Sahan-Firat, Seyhan, Korkmaz, Belma, Falck, John R., Malik, Kafait U.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774147/
https://ncbi.nlm.nih.gov/pubmed/22975359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.prostaglandins.2012.08.007
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