Connexin 43 hemichannels mediate the Ca(2+) influx induced by extracellular alkalinization

Although alkaline pH is known to trigger Ca(2+) influx in diverse cells, no pH-sensitive Ca(2+) channel has been identified. Here, we report that extracellular alkalinization induces opening of connexin 43 hemichannels (Cx43 HCs). Increasing extracellular pH from 7.4 to 8.5, in the presence of physi...

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Detalhes bibliográficos
Main Authors: Schalper, Kurt A., Sánchez, Helmuth A., Lee, Sung C., Altenberg, Guillermo A., Nathanson, Michael H., Sáez, Juan C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Membrane Transporters, Ion Channels and Pumps
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774097/
https://ncbi.nlm.nih.gov/pubmed/20881238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00015.2010
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