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Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation

Stromal derived follicular dendritic cells (FDCs) are a major reservoir for antigen that is essential for formation of germinal centers, the site where memory and effector B cells differentiate. A long-standing question is how FDCs retain antigen in its native form for extended periods and how they...

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Main Authors: Heesters, Balthasar A., Chatterjee, Priyadarshini, Kim, Young-A, Gonzalez, Santiago F., Kuligowski, Michael P., Kirchhausen, Tomas, Carroll, Michael C.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773956/
https://ncbi.nlm.nih.gov/pubmed/23770227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.02.023
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