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Single DNA Molecule Patterning for High-Throughput Epigenetic Mapping
We present a method for profiling the 5-methyl cytosine distribution on single DNA molecules. Our method combines soft-lithography and molecular elongation to form ordered arrays of more than 250,000 individual DNA molecules immobilized on a solid substrate. The methylation state of the DNA is detec...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3773698/ https://ncbi.nlm.nih.gov/pubmed/21981444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac202506j |
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