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Hypoxia induces the overexpression of MicroRNA-21 in pancreatic cancer cells

BACKGROUND: Pancreatic cancer cells exist in a hypoxic microenvironment containing numerous factors which impact tumor survival, proliferation and metastasis. MicroRNAs (miRs) are differentially expressed in cancer but also altered by hypoxia. We hypothesized that hypoxia could induce miR-21 express...

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Detalhes bibliográficos
Main Authors: Mace, Thomas A., Collins, Amy L., Wojcik, Sylwia E., Croce, Carlo M., Lesinski, Gregory B., Bloomston, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773267/
https://ncbi.nlm.nih.gov/pubmed/23726431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2013.04.061
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