Quantification of 5-Methylcytosine and 5-Hydroxymethylcytosine in Genomic DNA from Hepatocellular Carcinoma Tissues by Capillary Hydrophilic-Interaction Liquid Chromatography/Quadrupole TOF Mass Spectrometry

BACKGROUND: 5-Methylcytosine (5-mC) is an important epigenetic modification involved in development and is frequently altered in cancer. 5-mC can be enzymatically converted to 5-hydroxymethylcytosine (5-hmC). 5-hmC modifications are known to be prevalent in DNA of embryonic stem cells and neurons, b...

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Hauptverfasser: Chen, Ming-Luan, Shen, Fan, Huang, Wei, Qi, Jia-Hui, Wang, Yinsheng, Feng, Yu-Qi, Liu, Song-Mei, Yuan, Bi-Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773166/
https://ncbi.nlm.nih.gov/pubmed/23344498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2012.193938
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