BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch Syndrome

BRAFV600E mutation in microsatellite unstable (MSI) CRCs virtually excludes Lynch Syndrome (LS). In microsatellite stable (MSS) CRC it predicts poor prognosis. We propose a universal CRC LS screening algorithm using concurrent reflex immunohistochemistry (IHC) for BRAFV600E and MMR proteins. We comp...

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Detalhes bibliográficos
Main Authors: Toon, Christopher W, Walsh, Michael J, Chou, Angela, Capper, David, Clarkson, Adele, Sioson, Loretta, Clarke, Stephen, Mead, Scott, Walters, Rhiannon J., Clendenning, Mark, Rosty, Christophe, Young, Joanne P., Win, Aung Ko, Hopper, John L., Crook, Ashley, von Deimling, Andreas, Jenkins, Mark A., Buchanan, Daniel B, Gill, Anthony J
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773060/
https://ncbi.nlm.nih.gov/pubmed/23797718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAS.0b013e31828f233d
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