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The human Np53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function
A naturally occurring p53 isoform that lacks 39 residues at the N-terminus (denoted ΔNp53), when expressed with wild-type p53 (WTp53), forms mixed ΔNp53:WTp53 tetramers and causes accelerated aging in mice. Cellular alterations specific to ΔNp53:WTp53 have been difficult to assess because ΔNp53 and...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3773055/ https://ncbi.nlm.nih.gov/pubmed/23734707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12108 |
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