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A mutational analysis of 48G7 reveals that somatic hypermutation affects both antibody stability and binding affinity
The monoclonal antibody 48G7 differs from its germline precursor by ten somatic mutations, a number of which appear to be functionally silent. We analyzed the effects of individual somatic mutations and combinations thereof on both antibody binding affinity and thermal stability. Individual somatic...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3773045/ https://ncbi.nlm.nih.gov/pubmed/23795814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja402927u |
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