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The interplay of structure and dynamics: Insights from a survey of HIV-1 Reverse Transcriptase Crystal Structures

HIV-1 reverse transcriptase is a critical drug target for HIV treatment, and understanding the exact mechanisms of its function and inhibition would significantly accelerate the development of new anti-HIV drugs. It is well known that structure plays a critical role in protein function, but for reve...

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Hlavní autoři: Seckler, James M., Leioatts, Nicholas, Miao, Hongyu, Grossfield, Alan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773008/
https://ncbi.nlm.nih.gov/pubmed/23720322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24325
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