Reduced susceptibility to all neuraminidase inhibitors of influenza H1N1 viruses with haemagglutinin mutations and mutations in non-conserved residues of the neuraminidase

OBJECTIVES: We characterized human H1N1 influenza isolate A/Hokkaido/15/02, which has haemagglutinin and neuraminidase mutations that reduce drug susceptibility to oseltamivir, zanamivir and peramivir. METHODS: One wild-type and three mutant viruses were isolated by plaque purification. Viruses were...

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Detalhes bibliográficos
Main Authors: McKimm-Breschkin, Jennifer L., Williams, Janelle, Barrett, Susan, Jachno, Kim, McDonald, Mandy, Mohr, Peter G., Saito, Takehiko, Tashiro, Masato
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772742/
https://ncbi.nlm.nih.gov/pubmed/23759505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkt205
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