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Adenosine Deaminase Modulation of Telomerase Activity and Replicative Senescence in Human CD8 T Lymphocytes

Increased proportions of CD8 T lymphocytes lacking expression of the CD28 costimulatory receptor have been documented during both aging and chronic infection with HIV-1, and their abundance correlates with numerous deleterious clinical outcomes. CD28-negative cells also arise in cell cultures of CD8...

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Autors principals: Parish, Stanley T., Kim, Sarah, Sekhon, Rekha K., Wu, Jennifer E., Kawakatsu, Yukako, Effros, Rita B.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772624/
https://ncbi.nlm.nih.gov/pubmed/20147632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903647
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