Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies

FTY720 (Fingolimod, Gilenya) is a sphingosine analog used as an immunosuppressant in multiple sclerosis patients. FTY720 is also a potent protein phosphatase 2A (PP2A)–activating drug (PAD). PP2A is a tumor suppressor found inactivated in different types of cancer. We show here that PP2A is inactive...

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Bibliografische gegevens
Hoofdauteurs: Oaks, Joshua J., Santhanam, Ramasamy, Walker, Christopher J., Roof, Steve, Harb, Jason G., Ferenchak, Greg, Eisfeld, Ann-Kathrin, Van Brocklyn, James R., Briesewitz, Roger, Saddoughi, Sahar A., Nagata, Kyosuke, Bittman, Robert, Caligiuri, Michael A., Abdel-Wahab, Omar, Levine, Ross, Arlinghaus, Ralph B., Quintas-Cardama, Alfonso, Goldman, John M., Apperley, Jane, Reid, Alistair, Milojkovic, Dragana, Ziolo, Mark T., Marcucci, Guido, Ogretmen, Besim, Neviani, Paolo, Perrotti, Danilo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2013
Onderwerpen:
Myeloid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772499/
https://ncbi.nlm.nih.gov/pubmed/23926298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-492181
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