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SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria
Mutations in PTEN-induced putative kinase 1 (PINK1) or parkin cause autosomal recessive forms of Parkinson's disease. Recent work suggests that loss of mitochondrial membrane potential stabilizes PINK1 and that accumulated PINK1 recruits parkin from the cytoplasm to mitochondria for elimination...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Cell Biology
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3771941/ https://ncbi.nlm.nih.gov/pubmed/23885119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-01-0016 |
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