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A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1: ACTIVATION OF AKT VIA MTORC2
Accumulating evidence indicates that dysfunction of mitochondria is a common feature of Parkinson disease. Functional loss of a familial Parkinson disease-linked gene, BRPK/PINK1 (PINK1), results in deterioration of mitochondrial functions and eventual neuronal cell death. A mitochondrial chaperone...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044975/ https://ncbi.nlm.nih.gov/pubmed/21177249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.179390 |
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