Anti-Tumor Activity of a miR-199-dependent Oncolytic Adenovirus

The down-regulation of miR-199 occurs in nearly all primary hepatocellular carcinomas (HCCs) and HCC cell lines in comparison with normal liver. We exploited this miR-199 differential expression to develop a conditionally replication-competent oncolytic adenovirus, Ad-199T, and achieve tumor-specifi...

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Main Authors: Callegari, Elisa, Elamin, Bahaeldin K., D’Abundo, Lucilla, Falzoni, Simonetta, Donvito, Giovanna, Moshiri, Farzaneh, Milazzo, Maddalena, Altavilla, Giuseppe, Giacomelli, Luciano, Fornari, Francesca, Hemminki, Akseli, Di Virgilio, Francesco, Gramantieri, Laura, Negrini, Massimo, Sabbioni, Silvia
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771938/
https://ncbi.nlm.nih.gov/pubmed/24069256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073964
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