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Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system

Methionine metabolism is disrupted in patients with alcoholic liver disease, resulting in altered hepatic concentrations of S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), and other metabolites. The present study tested the hypothesis that reductive stress mediates the effects of ethanol o...

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Autors principals: Watson, Walter H., Song, Zhenyuan, Kirpich, Irina A., Deaciuc, Ion V., Chen, Theresa, McClain, Craig J.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771647/
https://ncbi.nlm.nih.gov/pubmed/21296661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2011.01.016
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