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Prognostic and predictive impact of DNA mismatch repair in the management of colorectal cancer
Colorectal cancers develop via two major pathways that Include chromosomal instability and microsatellite Instability. Microsatellite Instability occurs due to deficient DNA mismatch repair (MMR), which can be caused by epigenetic silencing of the MLH1 MMR gene in sporadic colorectal cancers or germ...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770934/ https://ncbi.nlm.nih.gov/pubmed/21417908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fon.11.5 |
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