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Prognostic and predictive impact of DNA mismatch repair in the management of colorectal cancer

Colorectal cancers develop via two major pathways that Include chromosomal instability and microsatellite Instability. Microsatellite Instability occurs due to deficient DNA mismatch repair (MMR), which can be caused by epigenetic silencing of the MLH1 MMR gene in sporadic colorectal cancers or germ...

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Detalhes bibliográficos
Main Authors: Sinicropet, Frank A, Yang, Zhineng Jayson
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770934/
https://ncbi.nlm.nih.gov/pubmed/21417908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fon.11.5
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