WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition

Actively transcribed genes are enriched with the histone variant H3.3. Although H3.3 deposition has been linked to transcription, mechanisms controlling this process remain elusive. We investigated the role of the histone methyltransferase Wolf–Hirschhorn syndrome candidate 1 (WHSC1) (NSD2/MMSET) in...

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Main Authors: Sarai, Naoyuki, Nimura, Keisuke, Tamura, Tomohiko, Kanno, Tomohiko, Patel, Mira C, Heightman, Tom D, Ura, Kiyoe, Ozato, Keiko
Format: Artigo
Sprog:Inglês
Udgivet: European Molecular Biology Organization 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770338/
https://ncbi.nlm.nih.gov/pubmed/23921552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.176
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