BRD4 Coordinates Recruitment of Pause Release Factor P-TEFb and the Pausing Complex NELF/DSIF To Regulate Transcription Elongation of Interferon-Stimulated Genes

RNA polymerase II (Pol II) and the pausing complex, NELF and DSIF, are detected near the transcription start site (TSS) of many active and silent genes. Active transcription starts when the pause release factor P-TEFb is recruited to initiate productive elongation. However, the mechanism of P-TEFb r...

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Main Authors: Patel, Mira C., Debrosse, Maxime, Smith, Matthew, Dey, Anup, Huynh, Walter, Sarai, Naoyuki, Heightman, Tom D., Tamura, Tomohiko, Ozato, Keiko
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700095/
https://ncbi.nlm.nih.gov/pubmed/23589332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01180-12
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