Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast

Heterochromatin assembly in fission yeast depends on the Clr4 histone methyltransferase, which targets H3K9. We show that the histone deacetylase Sir2 is required for Clr4 activity at telomeres, but acts redundantly with Clr3 histone deacetylase to maintain centromeric heterochromatin. However, Sir2...

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Hlavní autoři: Alper, Benjamin J, Job, Godwin, Yadav, Rajesh K, Shanker, Sreenath, Lowe, Brandon R, Partridge, Janet F
Médium: Artigo
Jazyk:Inglês
Vydáno: European Molecular Biology Organization 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770337/
https://ncbi.nlm.nih.gov/pubmed/23771057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.143
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