Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast

Heterochromatin assembly in fission yeast depends on the Clr4 histone methyltransferase, which targets H3K9. We show that the histone deacetylase Sir2 is required for Clr4 activity at telomeres, but acts redundantly with Clr3 histone deacetylase to maintain centromeric heterochromatin. However, Sir2...

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Main Authors: Alper, Benjamin J, Job, Godwin, Yadav, Rajesh K, Shanker, Sreenath, Lowe, Brandon R, Partridge, Janet F
Formato: Artigo
Idioma:Inglês
Publicado: European Molecular Biology Organization 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770337/
https://ncbi.nlm.nih.gov/pubmed/23771057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.143
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