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Elimination of T cell reactivity to pancreatic β cells and partial preservation of β cell activity by peptide blockade of LFA-1:ICAM-1 interaction in the NOD mouse model

In insulin dependent diabetes mellitus (T1D), self-reactive T cells infiltrate pancreatic islets and induce beta cell destruction and dysregulation of blood glucose. A goal is to control only the self-reactive T cells, leaving the remainder of the T cell population free to protect the host. One appr...

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Detalhes bibliográficos
Main Authors: Dotson, Abby L., Novikova, Lesya, Stehno-Bittel, Lisa, Benedict, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770271/
https://ncbi.nlm.nih.gov/pubmed/23770626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2013.04.016
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