COP1 and GSK3β Cooperate to Promote c-Jun Degradation and Inhibit Breast Cancer Cell Tumorigenesis

High abundance of c-Jun is detected in invasive breast cancer cells and aggressive breast tumor malignancies. Here, we demonstrate that a major cause of high c-Jun abundance in invasive breast cancer cells is prolonged c-Jun protein stability owing to poor poly-ubiquitination of c-Jun. Among the kno...

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Main Authors: Shao, Jing, Teng, Yong, Padia, Ravi, Hong, Sungguan, Noh, Hyangsoon, Xie, Xiayang, Mumm, Jeff S, Dong, Zheng, Ding, Han-Fei, Cowell, John, Kim, Jaejik, Han, Jiahuai, Huang, Shuang
格式: Artigo
語言:Inglês
出版: Neoplasia Press Inc. 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769886/
https://ncbi.nlm.nih.gov/pubmed/24027432
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