The effect of Echinacea purpurea on the pharmacokinetics of docetaxel

AIMS: The herbal medicine Echinacea purpurea (E. purpurea) has been shown to induce cytochrome P450 3A4 (CYP3A4) both in vitro and in humans. This study explored whether E. purpurea affects the pharmacokinetics of the CYP3A4 substrate docetaxel in cancer patients. METHODS: Ten evaluable cancer patie...

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Main Authors: Goey, Andrew K L, Meijerman, Irma, Rosing, Hilde, Burgers, Jacobus A, Mergui-Roelvink, Marja, Keessen, Marianne, Marchetti, Serena, Beijnen, Jos H, Schellens, Jan H M
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 2013
主題:
Drug Interactions
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769673/
https://ncbi.nlm.nih.gov/pubmed/23701184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12159
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