A published pharmacogenetic algorithm was poorly predictive of tacrolimus clearance in an independent cohort of renal transplant recipients

AIMS: An algorithm based on the CYP3A5 genotype to predict tacrolimus clearance to inform the optimal initial dose was derived using data from the DeKAF study (Passey et al. Br J Clin Pharmacol 2011; 72: 948–57) but was not tested in an independent cohort of patients. Our aim was to test whether the...

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Detalles Bibliográficos
Main Authors: Boughton, Oliver, Borgulya, Gabor, Cecconi, Maurizio, Fredericks, Salim, Moreton-Clack, Michelle, MacPhee, Iain A M
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2013
Assuntos:
Pharmacokinetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769669/
https://ncbi.nlm.nih.gov/pubmed/23305195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12076
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