Determining Population and Developmental Pharmacokinetics of Metronidazole Using Plasma and Dried Blood Spot Samples from Premature Infants

BACKGROUND: Limited pharmacokinetic (PK) data of metronidazole in premature infants has led to various dosing recommendations. Surrogate efficacy targets for metronidazole are ill-defined and therefore aimed to exceed minimum inhibitory concentration of organisms responsible for intra-abdominal infe...

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Main Authors: Cohen-Wolkowiez, Michael, Sampson, Mario, Bloom, Barry T., Arrieta, Antonio, Wynn, James L., Martz, Karen, Harper, Barrie, Kearns, Gregory L., Capparelli, Edmund V., Siegel, David, Benjamin, Daniel K., Smith, P. Brian
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769518/
https://ncbi.nlm.nih.gov/pubmed/23587979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/INF.0b013e3182947cf8
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