Germline Missense Variants in the BTNL2 Gene Are Associated with Prostate Cancer Susceptibility

BACKGROUND: Rare, inherited mutations account for 5%–10% of all prostate cancer (PCa) cases. However, to date, few causative mutations have been identified. METHODS: To identify rare mutations for PCa, we performed whole-exome sequencing (WES) in multiple kindreds (n = 91) from 19 hereditary prostat...

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Hlavní autoři: FitzGerald, Liesel M., Kumar, Akash, Boyle, Evan A., Zhang, Yuzheng, McIntosh, Laura M., Kolb, Suzanne, Stott-Miller, Marni, Smith, Tiffany, Karyadi, Danielle M., Ostrander, Elaine A., Hsu, Li, Shendure, Jay, Stanford, Janet L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769499/
https://ncbi.nlm.nih.gov/pubmed/23833122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-13-0345
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