Novel Fluorine-18 PET Radiotracers Based on Flumazenil for GABA(A) Imaging in the Brain

INTRODUCTION: Two 7-fluoroimidazobenzodiazepines (AH114726 and GEH120348), analogs of flumazenil, were labeled with fluorine-18 and evaluated as alternative radioligands for in vivo imaging of the GABA(A)/benzodiazepine receptor by comparing them to [(11)C]flumazenil in rhesus monkey. METHODS: Radio...

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Hauptverfasser: Rodnick, Melissa E., Hockley, Brian G., Sherman, Phillip, Quesada, Carole, Battle, Mark R., Jackson, Alexander, Linder, Karen E., Macholl, Sven, Trigg, William J., Kilbourn, Michael R., Scott, Peter J. H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769461/
https://ncbi.nlm.nih.gov/pubmed/23890694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2013.06.004
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