Expression of the Chemokine Receptor CXCR7 in CXCR4-Expressing Human 143B Osteosarcoma Cells Enhances Lung Metastasis of Intratibial Xenografts in SCID Mice

More effective treatment of metastasizing osteosarcoma with a current mean 5-year survival rate of less than 20% requires more detailed knowledge on mechanisms and key regulatory molecules of the complex metastatic process. CXCR4, the receptor of the chemokine CXCL12, has been reported to promote tu...

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Main Authors: Brennecke, Patrick, Arlt, Matthias J. E., Muff, Roman, Campanile, Carmen, Gvozdenovic, Ana, Husmann, Knut, Holzwarth, Nathalie, Cameroni, Elisabetta, Ehrensperger, Felix, Thelen, Marcus, Born, Walter, Fuchs, Bruno
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769403/
https://ncbi.nlm.nih.gov/pubmed/24040160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074045
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