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Membrane Lipid-Modulated Mechanism of Action and Non-Cytotoxicity of Novel Fungicide Aminoglycoside FG08

A novel aminoglycoside, FG08, that differs from kanamycin B only by a C8 alkyl chain at the 4″-O position, was previously reported. Unlike kanamycin B, FG08 shows broad-spectrum fungicidal but not anti-bacterial activities. To understand its specificity for fungi, the mechanism of action of FG08 was...

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Autors principals: Shrestha, Sanjib, Grilley, Michelle, Fosso, Marina Y., Chang, Cheng-Wei T., Takemoto, Jon Y.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769384/
https://ncbi.nlm.nih.gov/pubmed/24040088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073843
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