Hypoxia-Inducible Factor-1alpha and MAPK Co-Regulate Activation of Hepatic Stellate Cells upon Hypoxia Stimulation

BACKGROUND: Hepatic stellate cell (HSC) plays a key role in pathogenesis of liver fibrosis. During liver injury, hypoxia in local micro-environment is inevitable. Hif-1α is the key transcriptional regulation factor that induces cell’s adaptive responses to hypoxia. Recently, it was reported that MAP...

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Main Authors: Wang, Yueqin, Huang, Yimin, Guan, Fei, Xiao, Yan, Deng, Jing, Chen, Huoying, Chen, Xiaolin, Li, Jianrong, Huang, Hanju, Shi, Chunwei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769364/
https://ncbi.nlm.nih.gov/pubmed/24040163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074051
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