Integrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2

The mechanisms whereby guanine nucleotide exchange factors (GEFs) coordinate their subcellular targeting to their activation of small GTPases remain poorly understood. Here we analyzed how membranes control the efficiency of human BRAG2, an ArfGEF involved in receptor endocytosis, Wnt signaling, and...

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Bibliographic Details
Main Authors: Aizel, Kaheina, Biou, Valérie, Navaza, Jorge, Duarte, Lionel V., Campanacci, Valérie, Cherfils, Jacqueline, Zeghouf, Mahel
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769224/
https://ncbi.nlm.nih.gov/pubmed/24058294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001652
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