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Integrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2

The mechanisms whereby guanine nucleotide exchange factors (GEFs) coordinate their subcellular targeting to their activation of small GTPases remain poorly understood. Here we analyzed how membranes control the efficiency of human BRAG2, an ArfGEF involved in receptor endocytosis, Wnt signaling, and...

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Detalles Bibliográficos
Main Authors: Aizel, Kaheina, Biou, Valérie, Navaza, Jorge, Duarte, Lionel V., Campanacci, Valérie, Cherfils, Jacqueline, Zeghouf, Mahel
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769224/
https://ncbi.nlm.nih.gov/pubmed/24058294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001652
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