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Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA
Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule cell progenitors (cGCPs) and its aberrant activation causes a cerebellar cancer medulloblastoma. Pituitary adenylate cyclase activating polypeptide (PACAP) inhibits Shh-driven proliferation of cGCPs and acts as tumor...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3768265/ https://ncbi.nlm.nih.gov/pubmed/23872071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.07.012 |
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