Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA

Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule cell progenitors (cGCPs) and its aberrant activation causes a cerebellar cancer medulloblastoma. Pituitary adenylate cyclase activating polypeptide (PACAP) inhibits Shh-driven proliferation of cGCPs and acts as tumor...

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Hlavní autoři: Niewiadomski, Pawel, Zhujiang, Annie, Youssef, Mary, Waschek, James A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3768265/
https://ncbi.nlm.nih.gov/pubmed/23872071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.07.012
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