Autoantibodies in Scurfy Mice and IPEX Patients Recognize Keratin 14

Scurfy mice have a deletion in the Foxp3 gene, resulting in a failure to generate Foxp3(+) regulatory T cells, and they subsequently develop severe CD4(+) T-cell-mediated autoimmune inflammation. Multiple organs are involved, but the skin is one of the main organs affected. During the course of dise...

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Hauptverfasser: Huter, Eva N., Natarajan, Kannan, Torgerson, Troy R., Glass, Deborah D., Shevach, Ethan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767981/
https://ncbi.nlm.nih.gov/pubmed/20147963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2010.16
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