Targeting Gastrin-Releasing Peptide Suppresses Neuroblastoma Progression via Upregulation of PTEN Signaling

We have previously demonstrated the role of gastrin-releasing peptide (GRP) as an autocrine growth factor for neuroblastoma. Here, we report that GRP silencing regulates cell signaling involved in the invasion-metastasis cascade. Using a doxycycline inducible system, we demonstrate that GRP silencin...

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Main Authors: Paul, Pritha, Qiao, Jingbo, Kim, Kwang Woon, Romain, Carmelle, Lee, Sora, Volny, Natasha, Mobley, Bret, Correa, Hernan, Chung, Dai H.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767701/
https://ncbi.nlm.nih.gov/pubmed/24039782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072570
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