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Human α-l-iduronidase uses its own N-glycan as a substrate-binding and catalytic module

N-glycosylation is a major posttranslational modification that endows proteins with various functions. It is established that N-glycans are essential for the correct folding and stability of some enzymes; however, the actual effects of N-glycans on their activities are poorly understood. Here, we sh...

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Detalhes bibliográficos
Main Authors: Maita, Nobuo, Tsukimura, Takahiro, Taniguchi, Takako, Saito, Seiji, Ohno, Kazuki, Taniguchi, Hisaaki, Sakuraba, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767532/
https://ncbi.nlm.nih.gov/pubmed/23959878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306939110
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