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Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model

Metastasis is the major reason for breast cancer-related deaths. Although there is a host of indirect evidence for a role of PKCα in primary breast cancer growth, its role in the molecular pathways leading to metastasis have not been comprehensively studied. By treating mice with αV5-3, a novel pept...

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Autors principals: Kim, Jeewon, Thorne, Stephen H., Sun, Lihan, Huang, Baocheng, Mochly-Rosen, Daria
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767436/
https://ncbi.nlm.nih.gov/pubmed/20856202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.415
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