NOVEL ATYPICAL PKC INHIBITORS PREVENT VASCULAR ENDOTHELIAL GROWTH FACTOR-INDUCED BLOOD-RETINAL BARRIER DYSFUNCTION

Pro-inflammatory cytokines and growth factors such as vascular endothelial growth factor (VEGF) contribute to the loss of the blood-retinal barrier (BRB) and subsequent macular edema in various retinal pathologies. VEGF signaling requires conventional PKC (PKCβ) activity; however, PKCβ inhibition on...

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Hlavní autoři: Titchenell, Paul M., Lin, Cheng-Mao, Keil, Jason M., Sundstrom, Jeffrey M., Smith, Charles D., Antonetti, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767384/
https://ncbi.nlm.nih.gov/pubmed/22721706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20111961
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