Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics

BACKGROUND: Amyotrophic lateral sclerosis (ALS)-linked fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is concentrated within cytoplasmic stress granules under conditions of induced stress. Since only the mutants, but not the endogenous wild-type FUS, are associated with stress granule...

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Main Authors: Baron, Desiree M, Kaushansky, Laura J, Ward, Catherine L, Sama, Reddy Ranjith K, Chian, Ru-Ju, Boggio, Kristin J, Quaresma, Alexandre J C, Nickerson, Jeffrey A, Bosco, Daryl A
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766239/
https://ncbi.nlm.nih.gov/pubmed/24090136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-8-30
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