Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules

Mutations in the RNA-binding protein FUS (fused in sarcoma) are linked to amyotrophic lateral sclerosis (ALS), but the mechanism by which these mutants cause motor neuron degeneration is not known. We report a novel ALS truncation mutant (R495X) that leads to a relatively severe ALS clinical phenoty...

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Bibliografische gegevens
Hoofdauteurs: Bosco, Daryl A., Lemay, Nathan, Ko, Hae Kyung, Zhou, Hongru, Burke, Chris, Kwiatkowski, Thomas J., Sapp, Peter, McKenna-Yasek, Diane, Brown, Robert H., Hayward, Lawrence J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981014/
https://ncbi.nlm.nih.gov/pubmed/20699327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq335
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