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Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules
Mutations in the RNA-binding protein FUS (fused in sarcoma) are linked to amyotrophic lateral sclerosis (ALS), but the mechanism by which these mutants cause motor neuron degeneration is not known. We report a novel ALS truncation mutant (R495X) that leads to a relatively severe ALS clinical phenoty...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2981014/ https://ncbi.nlm.nih.gov/pubmed/20699327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq335 |
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