Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor

BACKGROUND: Advanced glycation end products (AGEs) and receptor RAGE interaction play a role in diabetic vascular complications. Inhibition of dipeptidyl peptidase-4 (DPP-4) is a potential therapeutic target for type 2 diabetes. However, the role of DPP-4 in AGE-induced endothelial cell (EC) damage...

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Main Authors: Ishibashi, Yuji, Matsui, Takanori, Maeda, Sayaka, Higashimoto, Yuichiro, Yamagishi, Sho-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765742/
https://ncbi.nlm.nih.gov/pubmed/23984879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-12-125
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