Fate of TLR-1/TLR-2 agonist functionalised pDNA nanoparticles upon deposition at the human bronchial epithelium in vitro

BACKGROUND: Plasmid DNA vaccination is a promising approach, but studies in non-human primates and humans failed to achieve protective immunity. To optimise this technology further with focus on pulmonary administration, we developed and evaluated an adjuvant-equipped DNA carrier system based on the...

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Detaylı Bibliyografya
Asıl Yazarlar: Heuking, Simon, Rothen-Rutishauser, Barbara, Raemy, David Olivier, Gehr, Peter, Borchard, Gerrit
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2013
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765319/
https://ncbi.nlm.nih.gov/pubmed/23964697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3155-11-29
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