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Nanocarriers for DNA Vaccines: Co-Delivery of TLR-9 and NLR-2 Ligands Leads to Synergistic Enhancement of Proinflammatory Cytokine Release

Adjuvants enhance immunogenicity of vaccines through either targeted antigen delivery or stimulation of immune receptors. Three cationic nanoparticle formulations were evaluated for their potential as carriers for a DNA vaccine, and muramyl dipeptide (MDP) as immunostimulatory agent, to induce and i...

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Publicado en:Nanomaterials (Basel)
Autores principales: Poecheim, Johanna, Heuking, Simon, Brunner, Livia, Barnier-Quer, Christophe, Collin, Nicolas, Borchard, Gerrit
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5304807/
https://ncbi.nlm.nih.gov/pubmed/28347123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nano5042317
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