Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy

BACKGROUND: Tubulo-interstitial nephropathy (TIN) is a common cause of chronic kidney disease (CKD). Consumption of an adenine-containing diet causes the accumulation of 2,8-dihydroxyadenine in the renal tubules triggering intense chronic TIN and progressive CKD in rats. CKD in this model is associa...

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Bibliografske podrobnosti
Main Authors: Aminzadeh, Mohammad A., Nicholas, Susanne B., Norris, Keith C., Vaziri, Nosratola D.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765021/
https://ncbi.nlm.nih.gov/pubmed/23512109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gft022
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